11th April 2025

On March 21, we’ll have fun our 10th LDV Imaginative and prescient Summit Anniversary! It’s a premier world gathering for folks within the visible tech sector. Yearly we convey collectively a powerful array of good audio system, starting from tech giants to under-the-radar startups, esteemed analysis labs and main enterprise capital corporations.

We’re thrilled to announce the fireplace chat between LDV Capital’s Evan Nisselson and Roelof Botha, Managing Associate and Steward of Sequoia Capital.

Roelof has spent over 20 years constructing corporations in Silicon Valley. He started inside the partitions of nascent PayPal, which he joined in March 2000 whereas finishing his MBA at Stanford. He grew to become CFO in 2001 and led the corporate by means of each its IPO in early 2002 and the following acquisition by eBay. Roelof joined Sequoia in 2003 to assist founders construct enduring companies. In 2017, he assumed management of Sequoia Capital’s US/Europe enterprise and have become a Steward of the Sequoia Partnership. Roelof is a Director of 23andMe, Block, Ethos, Inside.com, Landis, mmhmm, MongoDB, Natera, Pendulum Therapeutics, and Unity Applied sciences, and lately led Sequoia’s funding in Meeno. Beforehand, he was a Director of corporations that embrace YouTube, Tumblr, Xoom, Eventbrite, and Evernote. He additionally led Sequoia’s funding in Instagram.

Roelof and Evan will focus on traits and early-stage funding alternatives in companies leveraging visible applied sciences and AI. Register to get your free ticket in the present day!

Within the lead-up to the Summit, Evan had the privilege of asking Roelof a couple of questions.

Evan: We’ve recognized one another since once I was an entrepreneur and also you had simply joined Sequoia. As you recognize, we proceed investing within the identical thesis that has not modified since founding LDV Capital in 2012. The vast majority of knowledge our brains analyze is visible so nearly all of knowledge that AI will analyze shall be visible as nicely. Visible knowledge and visible applied sciences are essential for the success of synthetic intelligence horizontally throughout all sectors. Which enterprise sectors leveraging visible applied sciences are you most enthusiastic about over the subsequent 10 years?

Roelof: I’m most enthusiastic about using multimodal fashions in healthcare, the place expertise can harness medical information (textual content) and medical photographs (MRIs, CT scans, and so on.) to help physicians in scientific selections.

Roelof Botha at Base Camp, Sequoia’s annual get-together for 150+ of their portfolio firm founders, in 2022.

Evan: You could have invested in a wide range of very profitable companies that leverage visible applied sciences, reminiscent of Unity, Instagram, Tumblr, YouTube, amongst others. A few of these corporations have been began over 10 years in the past. Expertise developments and entrepreneurs evolve over time. Do you’re feeling entrepreneurs constructing companies powered by visible applied sciences in the present day ought to do something completely different than entrepreneurs did 10 years in the past?

Roelof: Along with innovating in core expertise, in the present day’s entrepreneurs must also spend time exploring distribution improvements. Unity and Instagram profit from the rise of cell gadgets and app shops, with Unity innovating with a freemium enterprise mannequin to achieve developer adoption. YouTube developed an embed resolution to assist web sites effortlessly host movies, which helped the service achieve speedy adoption within the early years. YouTube additionally benefited from viral progress, as customers shared hyperlinks by means of messaging providers.

Evan: I absolutely agree together with your assertion: “Should you’re going to be actually profitable on this enterprise, it’s important to be contrarian—and proper.” As an entrepreneur, folks usually stated I used to be loopy and since founding LDV Capital in 2012, folks felt our thesis was too slender and that we have been loopy investing in folks constructing powered by visible tech/AI. In your Sequoia bio web page, you write, “So many occasions, I’ve led an funding and been made enjoyable of. YouTube. Instagram. MongoDB…” What parameters, if any, provide help to gauge your degree of contrarian?

Roelof: I might take into account two measures. The primary is how controversial the choice is inside our partnership. YouTube was not an apparent funding on the time, nor was MongoDB, nor was Unity, nor was Sq.. We had spirited debates about every earlier than deciding to commit as a group to partnering with the founders. The second is how controversial the choice is within the view of the general public, particularly the response of the press. It’s necessary to metal your self to the naysayers who query your judgment. Whereas I used to be nonetheless at PayPal, I bear in mind an article that stated “Earth to Palo Alto” which mocked our quest to construct a profitable funds enterprise.

Evan: What was your most important studying expertise whereas working at PayPal that continues that will help you succeed in the present day?

Roelof: By no means hand over!

PayPal went public in 2002.

Evan: Sequoia’s mission helps “the daring construct legendary corporations from concept to IPO and past.” What’s your recommendation to entrepreneurs who need to begin a brand new enterprise?

Roelof: Focus in your buyer. What drawback are you fixing for them, and is your resolution compelling and distinctive in assembly your buyer’s wants? One other approach to say that is: “construct one thing helpful.”

Evan: What are you most trying ahead to at our 10th Annual LDV Imaginative and prescient Summit?

Roelof: Listening to the concepts of founders who need to change the world, and having my view of the world upended (once more).

RSVP to hitch us on March 21. Our classes will provide insights into cutting-edge AI, each empowering and disrupting companies. We hope they encourage you by offering concrete examples of how you can leverage these newest developments in your work.

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